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siRNA drug delivery across the blood-brain barrier in Alzheimer's Disease - PMC

The mTOR (mechanistic target of rapamycin) pathway, which regulates cellular growth and autophagy, becomes chronically overactivated with age, suppressing the cellular recycling processes that clear damaged components

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A controlled trial in 16 men and 20 women, aged 72 to 75 years, with low DHEA-S levels found 50 mg of DHEA daily for six months resulted in decreased fat mass and increased lean body mass