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Homocysteine and cardiovascular disease Observational studies indicate that even moderately elevated blood concentrations of homocysteine raise the risk of cardiovascular disease (CVD), although randomized controlled trials of homocysteine-lowering therapy have generally not translated to reductions in adverse cardiovascular outcomes (26, 27)

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Adequate B12 levels have been known to help prevent anemia and major birth defects, may support bone health, may reduce the risk of macular degeneration, and even help with mood improvement and symptoms of depression