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Abbreviations AEA anandamide AM404 N-arachidinoyl-phenolamine AMAP 3′-hydroxyacetanalide AMT anandamide membrane transporter ALF acute liver failure APAF-1 Apoptosis protease-activating factor-1 APAP acetaminophen ATP adenosine triphosphate CAR constitutive androstane receptor CB cannabinods receptors CNS central nervous system COXs cyclooxygenase CYP cytochrome P-450 isoenzymesmixed-function oxidase system DAMPs damage-associated molecular pattern molecules DNA Deoxyribonucleic acid ER endoplasmic reticulum FAAH fatty acid amide hydrolase GSH Glutathione GSSG glutathione disulfide HE hepatic encephalopathy HIF-1α Hypoxia-inducible factors HMGB1 high mobility group box-1 Ho-1 hemeoxygenase iNOS inducible nitric oxide synthase JNK c-Jun N-terminal kinase Keap1 Kelch-like ECH associated protein KO Knock-out MAPK mitogen-Activated MLKL mixed lineage kinase like is produce MPT membrane permeability transition NAC N acetyl-cysteine NAPQI N-acetyl-p-benzoquinoneimine Nec necrostatins NO nitric oxide Nqo1 NAD(P)H dehydrogenase quinone 1 Nrf2 nuclear factor erythroid 2–related factor 2 NSADs nonsteroidal anti-inflammatory drugs PINK1 phosphatase and tensin homolog (PTEN)-induced kinase 1 RIPK receptor interacting protein kinase ROS reactive oxygen species Sab Src homology 3 domain binding protein 5 TBP TATA-binding protein TRPV1 vanilloid subtype 1 receptors WT wild type XBP1 X-box binding protein-1 4-PBA Sodium 4-phenylbutyrate Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

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Researchers started every participant at the same base dose regardless of their target maintenance level, then increased the dose every four weeks until reaching the assigned tier