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These discoveries have enabled the development of animal models, which play a pivotal role in unraveling molecular pathways and advancing therapeutic interventions for AD (Lloyd et al., 2020)

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This imbalance between oxidant production and antioxidant defenses drives oxidative stress and formation of peroxynitrite, a highly cytotoxic effector molecule capable of inducing DNA, protein, and lipid damage, a pathological signature widely associated with neurodegeneration (212–215)