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Recent studies have explored small-molecule inducers, selenium-based compounds, and targeted nanodelivery approaches to restore GPX4 function or mimic its antioxidant capacity in ferroptosis-prone diseases, with therapeutic implications for OA and beyond ( In summary, GPX4 acts not only as a terminal antioxidant enzyme but also as a hub that integrates transcriptional, post-transcriptional, and nutritional cues

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Inflammatory cytokines like TNF-α further exacerbate this pathological loop [426]

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