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Hydroxyl free radicals released by CIS are involved in the phosphorylation of p38 MAPK and the regulation of TNF-α synthesis, leading to the activation of NF-κB [ 58 ]

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Below we integrate these principles with representative mechanisms and translational readouts, building on “Biological Sources and Subcellular Compartments of ROS–Crosstalk with RNS/RSS and iron” sections and the manuscript’s organizing framework