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Identifying sites vulnerable to proteolysis: Initial exploration of the structure–activity relationship (SAR), along with pharmacokinetic experiments, stability assays, and metabolite detection, aids in pinpointing proteolytically susceptible amide bonds within the sequence

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To adapt to increased mechanical forces, trabecular meshwork cells in the anterior eye, retinal ganglion cells and glia undergo structural and functional changes known as glaucomatous remodeling