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The anti-apoptotic members, Bcl-2 and Bcl-xL, preserve mitochondrial outer membrane integrity by binding to the pro-apoptotic protein Bax, which prevents mitochondrial cytochrome c release and maintains mitochondrial membrane integrity

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Newer classes of insecticides are now coming onto the market place for vector control, but the high cost of developing and registering them inevitably means that insecticides are developed initially for the agricultural market and then utilized for public health vector control, where their activities and safety profile are appropriate