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In ferric nitrilotriacetate-induced renal carcinogenesis models, H₂-rich water reduced early tumor-promoting events by modulating oxidative and inflammatory pathways.52 Likewise, during high-stress surgeries such as orthotopic liver transplantation, H₂ helped preserve renal function by attenuating oxidative injury and apoptosis.38,40 In obstetric complications like preeclampsia, H₂ therapy lowered blood pressure, reduced oxidative damage, and improved pregnancy outcomes.53 Studies on chronic intermittent hypoxia and renal injury secondary to cardiac surgery further illustrate H₂ systemic cytoprotective potential.32,38 Nonetheless, outcome variability across these diverse scenarios points to the need for further inquiry into optimal dosing regimens, patient selection, and long-term safety

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Macioszek VK, Jęcz T, Ciereszko I, Kononowicz AK