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It is noteworthy that during the initial phase of functional impairment in certain organs, such as liver injury, kidney injury, and cardiovascular disease, increased intestinal permeability and endotoxin release can be detected, which helps to identify some high-risk adverse events early (Lee et al., 2018)

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Likewise, the mentioned inability to activate the collateral pathways also resulted in harm to the failed vessels in alcohol intoxication syndrome [25], lithium intoxication syndrome [24], and isoprenaline-induced myocardial infarction syndrome [23] or maintained intra-abdominal hypertension, grade III and IV syndrome [22]