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A randomized placebo-controlled trial in 43 subjects with idiopathic facial palsy found those given 3 grams of oral acetyl-L-carnitine along with 50 mg methylprednisolone daily for 14 days had more rapid functional recovery of the facial nerve compared with those given methylprednisolone plus placebo

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Most published studies of rescue instillations were open-label without a placebo group, and the AUA's 2022 guideline lists DMSO, heparin, and/or lidocaine as an Option, its weakest level of endorsement, with modest evidence grades