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And absent more rigorous studies, the team warned, “it will remain difficult to convince the broader medical community that this so-called ‘wonderful’ compound meets the criteria of a legitimate therapeutic agent.” But it turns out, one group had begun to give it a go anyway

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Notably, autophagy dysfunction and metabolic disturbances form a vicious cycle - impaired autophagic flux exacerbates glucose and lipid metabolic imbalances (Kim and Lee, 2014), which may serve as a key driver for the progressive metabolic deterioration in DM (Figure 3)