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Duration of Supplementation and the Risk of Hypersensitivity to Vitamin B12 In many reported clinical cases of hypersensitivity reactions to vitamin B12 [9,10,11,12,13,82,83,84,85], it is noteworthy that allergic responses to the administered cobalamin developed after a long period of systematic therapy with cobalamin injections (different chemical forms)

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However, pharmacological inhibition of p38 or MEK1/2, using BIRB796, U0126, or SB203508 to block the downstream MAPK signal, did not increase TEER

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