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Methodologically, we advocate species-resolved, compartment-aware assessment—e.g., DHE → 2-OH-E⁺ HPLC for O 2· −, targeted HyPer/roGFP-Orp for H 2 O 2 and peroxiredoxin redox state—embedded in composite panels that pair flux with damage footprints and iron/ferroptosis metrics for attribution and trial guidance

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as inhibitors of free radical oxidation reaction

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