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Associations between imaging and neuropathic findings and phenotype have been found, 172,173 but no one has systematically assessed the extent to which documented brain architectural differences in individuals diagnosed with autism (a diagnosis that cannot presently be made prenatally or in the first year and a half of life) derive from altered prenatal neurodevelopmental processes as compared with tissue changes acquired over time from disturbances in key phenomena such as excitation/inhibition balance, bioenergetics, immune function, or other metabolic processes

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