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GTP cyclohydrolase 1 (GCH1), the rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, safeguards cellular membranes against ferroptosis by orchestrating antioxidant defense and lipid remodeling ( Regulatory networks, such as the p62-Keap1-NRF2 pathway, integrate cellular stress signals to modulate ferroptosis sensitivity ( 3 Interconnection between ferroptosis and lipid metabolism How cells store, remodel, and metabolize lipids can either exacerbate or mitigate lipid peroxidation, directly affecting their sensitivity to ferroptosis ( β -oxidation, phospholipid synthesis and remodeling, lipid storage, and release, interact with the cell’s antioxidant defenses to regulate ferroptosis sensitivity ( 3.1 Fatty acid synthesis The synthesis of saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs) is primarily mediated by enzymes such as acetyl-CoA carboxylase (ACC) and fatty acid synthase (FASN)

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doi: 10.1002/jmv.27837, [DOI] [PMC free article] [PubMed] [Google Scholar] Schäfer G., Kabanda S., Van Rooyen B., Marušič M