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To evaluate whether protein levels in APOE4 carriers would alter their Aβ positivity rates in CU and MCI, in BioFINDER-2 plasma SomaLogic cohort, we fit interaction models of the following form: Aβ status = β1 + β2 ( APOE4 × protein) + β3 APOE4 + β4 protein + covariates + ϵ