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A decline in the dendritic spine density (DSD) is an early characteristic feature of many neurodegenerative diseases ( in vivo correlates well with its in vitro ability to alter dendritic spine structure and DSD ( 23 (HA08) enhances the numbers of dendritic spines in hippocampal cell cultures and HA08 treatment resulted in an increasing number of stubby and mushroom-like spines, a morphology typically associated with mature spines, which are believed to have strengthened synaptic connectivity