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It directly inhibited the stearoyl-CoA desaturase-1 (SCD1) protein to trigger ferroptosis of ovarian cancer, evidenced by the increased ROS, total iron, and Fe 2+ levels and downregulation of ferroptosis inhibitors (SLC7A11 and GPX4), thus suppressing cancer progression in the SKOV-3 xenograft model ( Some TCM botanical drugs could induce ferroptosis of cancer cells, but the specific metabolites have not been identified or isolated

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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Liptak JM, Withrow SJ