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Damaged dopaminergic neurons release matrix metalloproteinase 3, α-synuclein, and neuromelanin that superactivated microglia, inducing reactive microgliosis, enhancing of the neurotoxicity-related mediators, such ROS (Figure 3)

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When it comes to CagriSema specifically, a clinical trial found that mild to moderate GI side effects were the most common (think: nausea, vomiting, and diarrhea), which were most likely to occur when the dose was increased