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Keywords: nondiabetics, obesity, overweight, tirzepatide Abbreviations AHI apnea–hypopnea index BMI body mass index CI confidence interval DM diabetes mellitus FDA Food and Drug Administration GI gastrointestinal GIP glucose‐dependent insulinotropic polypeptide GLP‐1 glucagon‐like peptide‐1 GLP‐1 RA glucagon‐like peptide‐1 receptor agonist HbA1C glycated hemoglobin HDL high‐density lipoprotein LDL low‐density lipoprotein MD mean difference MTD maximum tolerated dose OR odds ratio OSA obstructive sleep apnea PAP positive airway pressure PRISMA Preferred Reporting Items for Systematic Reviews and Meta‐Analyses RCT randomized controlled trial RoB 2 version 2 of the Cochrane risk‐of‐bias tool for randomized trials RR relative risk VLDL very‐low‐density lipoprotein 1