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In addition, the SOCS gene is activated by GH signaling and works as a short intracellular negative feedback loop which rapidly down-regulate GHR activity by internalization and receptor ubiquitinoylation resulting in lysosomal and proteasomal degradation (101)

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These neurological manifestations were induced by the interaction of N 2 O with vitamin B12 and did not resolve until N 2 O exposure was discontinued [12]

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