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Later, Schultze and coworkers suggested that the toxicity of DCVC is associated with a “C—S” lyase reaction and formation of a reactive sulfur-containing species that adds to macromolecules, including proteins and nucleic acids (e.g., Anderson and Schultze, 1965, Bhattacharya and Schultze, 1967, Bhattacharya and Schultze, 1972)