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The limited efficacy of even potent immunosuppression in the later stages (Wolinsky et al., 2020) is likely due to a waning of the acute/adaptive auto-immune component, rather than restricted access of biologicals to the CNS (as an example of adequate access of biologicals to the brain, systemic administration of anti-amyloid antibodies in Alzheimer’s has now been shown to be effective at reducing amyloid load (Jucker and Walker, 2023