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Moreover, the preponderance of studies remains confined to in vitro models, underscoring a pressing need for systematic in vivo investigations to validate clinical translatability under physiologically relevant conditions

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The discrepancy is too large to be dismissed as a chance finding, suggest the researchers, but could be the result of publication bias—some studies might have been prioritized for publication because of the positive nature of their results whereas the unpublished datasets used in this study would not have been affected by any failure to publish null results