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Folate is indeed one of the central nutrients in the methylation cycle and a deficiency can have serious effects – especially for the synthesis of important hormones and neurotransmitters such as serotonin Treatment with vitamin B12 and methylfolate can produce extremely good results for people who do not respond to regular antidepressants

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- PubMed - NCBI Exogenous testosterone: a preventable cause of male infertility - Crosnoe - Translational Andrology and Urology Maintenance of spermatogenesis in hypogonadotropic hypogonadal men with human chorionic gonadotropin alone