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33823377, 37083708, 36791631) In INH, gyromitra mushroom toxicity, or chronic oral hydralazine use, very high doses are used (e.g., 5 grams IV)

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Since equal amounts of all three polypeptide chains are needed to produce fibrinogen, when synthesis of one of the chain of fibrinogen is suppressed, it will have a general inhibitory effect on fibrinogen synthesis [44]