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Strains of Bifidobacterium species also participate in tryptophan metabolism in the gut, while its metabolite indole-3-carbaldehyde (I3C) directly binds to AhR ligands involved in immune signaling and inhibits abnormal immune responses 41,42
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Challenges persist, as HRD-negative patients exhibit limited responses to PARP inhibitors plus Bevacizumab, and genomic instability may accelerate clonal evolution
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